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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Heptavalent Botulism Antitoxin</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><p>Das <b>Heptavalent Botulism Antitoxin</b> (<i>H-BAT</i>, Eigenschreibweise des Herstellers Cangene: <i>Heptavalent Botulism AntiToxin</i>) ist eine Mischung von sieben verschiedenen <a href="Antik%C3%B6rper" title="Antikörper">Antikörpern</a>, die zur Behandlung von <a href="Botulismus" title="Botulismus">Botulismus</a> verwendet werden.
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<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p>Mit dem Heptavalent Botulism Antitoxin werden Vergiftungen mit <a href="Botulinumtoxin" title="Botulinumtoxin">Botulinumtoxinen</a> (<a href="Serotyp" title="Serotyp">Serotypen</a> A bis G) im Sinne einer <a href="Passive_Immunisierung" class="mw-redirect" title="Passive Immunisierung">passiven Immunisierung</a> behandelt. Die Antikörper wurden zuvor aus <a href="Blutserum" title="Blutserum">Seren</a> von immunisierten <a href="Pferde" title="Pferde">Pferden</a> <a href="Proteinreinigung" title="Proteinreinigung">gereinigt</a> und teilweise mit <a href="Pepsin" title="Pepsin">Pepsin</a> verdaut.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> H-BAT wird von der Firma <i>Cangene</i> hergestellt. Die experimentelle Verwendung beim Menschen wurde 2010 zugelassen, die generelle <a href="Arzneimittelzulassung" title="Arzneimittelzulassung">Arzneimittelzulassung</a> für die USA erfolgte 2013 und ersetzte zwei zuvor zugelassene Antikörpermischungen, das <i>bivalent botulinum antitoxin AB</i> und das <i>monovalent botulinum antitoxin E</i> (BAT-AB bzw. BAT-E).<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>
<ul><li>R. G. Hibbs, J. T. Weber, A. Corwin, B. M. Allos, M. S. Abd el Rehim, S. E. Sharkawy, J. E. Sarn, K. T. McKee: <i>Experience with the use of an investigational F(ab')2 heptavalent botulism immune globulin of equine origin during an outbreak of type E botulism in Egypt.</i> In: <i><a href="Clinical_Infectious_Diseases" title="Clinical Infectious Diseases">Clinical Infectious Diseases</a>.</i> Band 23, Nummer 2, August 1996, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221058-4838%22&key=cql">1058-4838</a></span></span>, S. 337–340, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/8842274?dopt=Abstract">PMID 8842274</a>.</li>
<li>R. F. Robinson, M. C. Nahata: <i>Management of botulism.</i> In: <i><a href="The_Annals_of_Pharmacotherapy" title="The Annals of Pharmacotherapy">The Annals of Pharmacotherapy</a>.</i> Band 37, Nummer 1, Januar 2003, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221060-0280%22&key=cql">1060-0280</a></span></span>, S. 127–131, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/12503947?dopt=Abstract">PMID 12503947</a>.</li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
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<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><a href="Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a>: <i>Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G) – (Equine) Treatment of Symptomatic Botulism. BLA 125462. Briefing Document for the Biologic Products Advisory Committee.</i> <a rel="nofollow" class="external text" href="http://www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/bloodvaccinesandotherbiologics/bloodproductsadvisorycommittee/ucm338855.pdf">(PDF)</a>.</span>
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<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><a href="Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">Centers for Disease Control and Prevention</a>: <i>Investigational heptavalent botulinum antitoxin (HBAT) to replace licensed botulinum antitoxin AB and investigational botulinum antitoxin E.</i> In: <i>MMWR. Morbidity and mortality weekly report.</i> Band 59, Nummer 10, März 2010, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221545-861X%22&key=cql">1545-861X</a></span></span>, S. 299, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/20300057?dopt=Abstract">PMID 20300057</a>.</span>
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